Table 2.
Medication Prevalence in Aspirin in Reducing Events in the Elderly Study Participants by Drug Class and Sex and Country
| Medication Class | Men | Women | Unadjusted Odds Ratioa (95% CI) | Australia | United States | Adjusted Odds Ratiob (95% CI) |
|---|---|---|---|---|---|---|
| Insulin | 1% 84 |
1% 73 |
0.67 (0.40–0.92) | 1% 105 |
2% 52 |
3.53 (2.49–4.94) |
| Oral glucose-lowering drugs | 7% 576 |
5% 526 |
0.69 (0.61–0.78) | 5% 825 |
11% 277 |
2.58 (2.22–2.98) |
| Proton pump inhibitors | 23% 1908 |
26% 2806 |
1.18 (1.11–1.27) | 26% 4422 |
12% 292 |
0.38 (0.34–0.43) |
| Diuretics | 15% 1212 |
22% 2346 |
1.63 (1.51–1.76) | 17% 2915 |
27% 643 |
1.68 (1.52–1.86) |
| β-blockers | 6% 479 |
10% 1075 |
1.82 (1.62–2.03) | 7% 1192 |
15% 362 |
2.27 (1.99–2.57) |
| Calcium channel antagonists | 17% 1395 |
18% 1907 |
1.07 (0.99–1.15) | 17% 2840 |
19% 462 |
1.2 (1.07–1.34) |
| Drugs acting on the RAA pathway | 40% 3319 |
43% 4656 |
1.15 (1.08–1.22) | 43% 7148 |
34% 827 |
0.7 (0.64–0.76) |
| Statins | 28% 2337 |
34% 3650 |
1.31 (1.23–1.4) | 31% 5158 |
34% 829 |
1.13 (1.03–1.24) |
| NSAIDs | 15% 1227 |
16% 1691 |
1.08 (0.99–1.17) | 15% 2586 |
14% 332 |
0.85 (0.75–0.96) |
| Opioids | 3% 258 |
5% 540 |
1.65 (1.42–1.92) | 4% 721 |
3% 77 |
0.71 (0.55–0.89) |
| Benzodiazepines | 4% 327 |
8% 878 |
2.17 (1.91–2.48) | 7% 1134 |
3% 71 |
0.41 (0.32–0.52) |
| Antidepressants | 7% 593 |
14% 1552 |
2.19 (1.99–2.43) | 12% 1924 |
9% 221 |
0.71 (0.61–0.82) |
CI = confidence interval; NSAIDs = nonsteroidal antiinflammatory drugs; RAA = renin-angiotensin-aldosterone.
World Health Organization Anatomical and Therapeutic Chemical codes used to define medication classes: insulins, A10A; oral glucose-lowering drugs, A10B; proton pump inhibitors, A02BC; diuretics, C03; β-blockers, C07; prevalence of calcium channel antagonists, C08; drugs acting on the RAA pathway, C09; statins, C10AA; NSAIDs, M01A; bisphosphonates, M05BA; opioids, N02A; benzodiazepines, N05CD and N05BA; and antidepressants, N06A.
Men (reference) versus women.
Adjusted for age and sex, Australia (reference) versus United States.