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. Author manuscript; available in PMC: 2021 May 1.
Published in final edited form as: Nat Metab. 2020 Oct 26;2(11):1232–1247. doi: 10.1038/s42255-020-00296-1

Fig. 7: Improved cardiac remodeling during fasting is associated with enhanced fat oxidation.

Fig. 7:

a-c, Blood glucose, plasma non-esterified fatty acid (NEFA), and plasma total ketone body concentrations from fed or 24 h-fasted mice (n=22, 15, 16, and 14 for fl/fl fed, CS-Mpc2−/− fed, fl/fl fasted, and CS-Mpc2−/− fasted, respectively). d, Heart weight normalized to tibia length after feeding or fasting (n=22, 15, 16, and 14 for fl/fl fed, CS-Mpc2−/− fed, fl/fl fasted, and CS-Mpc2−/− fasted, respectively). e-l, Cardiac gene expression markers of heart failure, fibrosis, or ketone and fatty acid metabolizing enzymes (n=8, 9, 7, and 6 for fl/fl fed, CS-Mpc2−/− fed, fl/fl fasted, and CS-Mpc2−/− fasted, respectively). m-o, Oxygen consumption rates (OCR) measured from permeabilized cardiac muscle fibers using pyruvate (Pyr) or palmitoyl-CoA with carnitine and malate (Palm-CoA/Carn/Mal) as substrates (n=9, 9, 9, and 7 for fl/fl fed, CS-Mpc2−/− fed, fl/fl fasted, and CS-Mpc2−/− fasted, respectively). Data are presented as mean ± s.e.m. within dot plot. Each symbol in dot plot represents an individual sample. Two-way ANOVA with Tukey’s multiple-comparisons test.