Skip to main content
. Author manuscript; available in PMC: 2021 May 1.
Published in final edited form as: Nat Metab. 2020 Oct 26;2(11):1232–1247. doi: 10.1038/s42255-020-00296-1

Fig. 8: Ketogenic diet can reverse heart failure in CS-Mpc2−/− mice.

Fig. 8:

a, Timeline for heart failure reversal experiment, in which CS-MPC2−/− mice were switched to low fat (LF) or ketogenic diet (KD) at 16 weeks of age for 3 weeks. b-d, Echocardiography measures of left ventricular (LV) mass index, end-diastolic volume (EDV), and ejection fraction (EF) of CS-MPC2−/− mice PRE and POST LF or KD feeding (n=3 LF, 5 KD; data presented as PRE-POST with first data point at 16-weeks old and second data point at 19-weeks old after 3 weeks of LF or KD). e, Plasma total ketone values from CS-MPC2−/− mice fed LF or KD (n=3 LF, 5 KD). f-g, Heart weight and lung weight normalized to tibia length (n=3 LF, 5 KD). h-j, Cardiac gene expression of hypertrophy, heart failure, fibrosis, and ketone body and fatty acid metabolizing genes (n=3 LF, 5 KD). Data presented either as PRE-POST, or mean ± s.e.m. shown within dot plot. Each symbol represents an individual sample. Two-tailed paired Student’s t test to compare PRE vs. POST, two-tailed unpaired Student’s t test to compare LF vs. KD.