Table 2.

Correlation of BRAF protein and gene expressions with the clinicopathological features in the colorectal cancer specimens

Variables	Braf protein intensity		BRAF gene expression		MIR17 expression		Log BRAF/MIR17 ratio
	PAss value	r (PCorr)	PAss value	r (PCorr)	PAss value	r (PCorr)	PAss value	r (PCorr)
Age	0.84	0.03 (0.82)	0.13	‐0.09 (0.48)	0.36	‐0.02 (0.85)	0.51	0.14 (0.31)
Sex	0.14	‐0.20 (0.14)	0.91	‐0.016 (0.91)	0.28	0.18 (0.18)	0.91	0.016 (0.91)
Grade	<0.001	0.72 (<0.001)	0.22	‐0.23 (0.09)	0.030	‐0.49 (<0.001)	0.001	‐0.52 (<0.001)
Site	0.74	0.10 (0.45)	0.39	0.09 (0.49)	0.49	‐0.19 (0.15)	0.95	0.03 (0.78)
T	0.003	0.41 (0.002)	0.09	‐0.23 (0.17)	0.31	‐0.15 (0.28)	<0.001	‐0.55 (<0.010)
N	0.22	0.24 (0.08)	0.21	0.03 (0.81)	0.29	‐0.28 (0.045)	0.011	‐0.39 (0.004)
M	0.44	0.10 (0.44)	0.85	‐0.02 (0.85)	0.52	‐0.08 (0.54)	0.07	‐0.24 (0.07)
Stage	0.43	0.15 (0.27)	0.28	0.05 (0.71)	0.69	‐0.20 (0.14)	0.16	‐0.32 (0.019)
LVI	0.58	0.07 (0.59)	0.042	0.28 (0.041)	0.051	‐0.08 (0.52)	0.19	0.18 (0.19)
Subtype	<0.001	0.61 (<0.001)	0.57	‐0.15 (0.25)	0.76	‐0.44 (0.001)	0.001	‐0.53 (<0.001)
Relapse	0.38	‐0.11 (0.39)	0.66	‐0.25 (0.06)	0.020	0.33 (0.015)	0.07	‐0.24 (0.07)
Died	0.27	0.15 (0.28)	0.77	‐0.03 (0.78)	0.54	‐0.05 (0.69)	0.06	‐0.25 (0.06)
DFS	0.027	‐0.31 (0.023)	0.75	‐0.03 (0.81)	0.17	0.06 (0.63)	<0.001	0.50 (<0.001)
OS	0.001	‐0.35 (0.011)	1.0	‐0.11 (0.42)	0.016	0.24 (0.08)	<0.001	0.41 (0.003)

P_Ass (p‐values of the association analysis) were calculated by Mann‐Whitney U or Kruskal‐Wallis tests. Spearman's correlation analysis is expressed as a correlation coefficient (r) and its p‐values (P_Corr). Bold values are statistically significant at p < 0.05.

Abbreviations: DFS, disease‐free survival; LVI, lymphovascular invasion; OS, overall survival.