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Error bars show 95% confidence limits for each measure. Pain: moderate or greater pain was defined as NRS pain ≥4 on the 10-unit scale (black points); severe pain as NRS pain ≥8 (grey points). Function: moderate or greater limitation of function was defined as function ≥20 on the 68-point WOMAC function scale (black points); severe loss of function was defined as ≥36 (grey points). TKR—risk of total knee replacement over follow-up period (up to 8 years, average follow up 5 years).
