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. 2021 Mar 2;22(5):2490. doi: 10.3390/ijms22052490

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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FA activated proton leak is preferably inhibited by ADP and ATP and maintains the substrate specificity of ANT. (a) Membrane conductance of lipid bilayers reconstituted with AA and ANT1 in the presence of different purine nucleotides. Lines are a least square regression fit of a sigmoidal function to the data. (b) EC50 and (c) maximum inhibition values as fit function parameters in (a). Values for GMP were dropped due to the low effect. For experimental conditions, see Figure 4. Data are the mean ± SD of at least three independent experiments.