Table 3. Effects of R¹ Substitution and Quinoline Modification of Benzimidazoles and Imidazopyridines on IDO1 Inhibitory Activity and in Vitro Metabolic Stability.

^aAbsolute stereochemistry is R-.

^bData reported as average test results (N = 3, unless otherwise noted). See Supporting Information for a description of assay conditions.

^chWB = human whole blood; data reported as average test results (N = 2, unless otherwise noted). See Supporting Information for a description of assay conditions.

^dFractions of the parent compound (0.5 μM) remaining after a 10 min incubation with 1 mg/mL of human, mouse, and rat liver microsomes (HLM, MsLM, RLM).