Table 2.
Summary table of identified QTLs related to NK cell parameters
| QTL | Phenotype | QTL region | P value | Founder effect | Number of SNPs | Number of genes | Top candidate genes |
| Significant peaks | |||||||
| NK1 | NK cell number in the lung | Chr. 13: 85.8–93.93 Mbp | 0.0077 | NZO high | 956 | 27 | Xrcc4, Zfyve16, Msh3, Atg10 |
| NK2 | NKp46 expression in hepatic NK cells | Chr. 7: 3.06–6.75 Mbp | 0.0018 | B6 and WSB low | 226 | 14 | Lair1, Tarm1 |
| NK3 | Frequency of CD94+ splenic NK cells | Chr. 6: 128.22–137 Mbp | 0.008 | CAST and WSB low | 417 | 47 | Clec2d, Etv6 |
| Suggestive peaks | |||||||
| NK4 | NK cell number in the mLN | Chr. 4: 102.89–142.91 Mbp | — | — | — | — | — |
| NK5 | Frequency of KLRG1+ NK cells in the liver and spleen | Chr. 19: 3.17–31.23 Mbp | — | — | — | — | — |
| NK6 | Frequency of CD11b+ splenic NK cells | Chr. 7: 36.03–134.99 Mbp | — | — | — | — | — |
| NK7 | Frequency of CD27/CD11b DP splenic NK cells | Chr. 10: 88.23–94.47 Mbp | — | — | — | — | — |
| NK8 | Chr. 13: 48.18–52.75 Mbp | — | — | — | — | — | |
| NK9 | Frequency of DNAM-1+ NK cells in the mLN | Chr. 2: 53.05–76.25 Mbp | — | — | — | — | — |
QTLs were considered as significant when P < 0.05 and suggestive when P < 0.2.