NUPR1 and the Epigenetic Landscape in Breast, Lung, and Colorectal Cancers. LncRNA FAL1 is overexpressed in colorectal cancer, and acts as a ‘sponge’ for miR-637, which negatively regulates NUPR1 expression. Similarly, oncRNA T3p binds to and inhibits miR-10b and miR-387c, which both negatively regulate NUPR1 expression in breast cancer. NUPR1 contributes to Cr(VI)-mediated cell transformation and carcinogenesis in lung cancer by negatively regulating MOF, resulting in reduced levels of H4K16ac and corresponding gene expression. NUPR1 increases H3K4me3, a well-known transcriptional activation mark. Created with
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