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. Author manuscript; available in PMC: 2021 Mar 15.
Published in final edited form as: J Am Chem Soc. 2020 Nov 9;142(46):19642–19651. doi: 10.1021/jacs.0c08964

Figure 1. Recent examples of biohybrid sequence defined polymers.

Figure 1.

A) Highly functionalized nucleic acids developed in the Liu lab.25,26 These structures can be amplified by PCR and sequenced and therefor used for aptamer selections. B) Modified PNA developed in the Heemstra group.24 Hydrophobic and hydrophilic side chains drive PNA self-assembly to supramolecular structures. C) This work: efficient synthesis and sequencing strategies for nucleobase peptides were developed, enabling discovery experiment from combinatorial libraries.