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. Author manuscript; available in PMC: 2021 Mar 15.
Published in final edited form as: J Am Chem Soc. 2020 Nov 9;142(46):19642–19651. doi: 10.1021/jacs.0c08964

Figure 4. Hybrid nucleobase peptides have higher bulk affinity to oligonucleotides than canonical peptides.

Figure 4.

A) Schematic representation of the ELISA assay: immobilized nucleobase peptide or canonical peptide library, respectively, is incubated with a biotinylated DNA library. B) ELISA readout diagram: nucleobase peptides have higher affinity towards DNA than canonical peptides.