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. 2021 Mar 2;26(5):1324. doi: 10.3390/molecules26051324

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Accuracy of the presented method regarding individual analytes, sums of the concentrations of acid and lactone forms (ATR + ATRL), and the sums of the concentrations of all analytes (ATR + MET). Results obtained at 20 spiking levels, and by spiking 20 independent serum samples at each spiking level, are shown. The horizontal lines indicate an accuracy of 100% (black), 85% and 115% (red). (A) Atorvastatin (filled circles) and atorvastatin lactone (hollow circles). (B) Combined concentrations of atorvastatin and atorvastatin lactone (ATR + ATRL). (C) 2-hydroxyatorvastatin (filled circles) and 2-hydroxyatorvastatin lactone (hollow circles). (D) Combined concentrations of 2-hydroxyatorvastatin and 2-hydroxyatorvastatin lactone (2OATR + 2OATRL). (E) 4-hydroxyatorvastatin (4OATR) (filled circles) and 4-hydroxyatorvastatin lactone (4OATRL) (hollow circles). (F) Combined concentrations of 4-hydroxyatorvastatin and 4-hydroxyatorvastatin lactone (4OATR + 4OATRL). (G) Combined concentrations of all analytes (ATR + MET).