Table 3.

Factors impacting nanoparticle toxicokinetics in C. elegans

Factor	Process(es) Likely Impacted	References
Presence of Food	Apparent External Dose, Uptake (delivery of compound by adsorption/internalization by bacteria, pharyngeal pumping rate)	(Yang et al 2014; 2017; Collin et al. 2014)
Environmental Transformation	Uptake, Distribution	(Starnes et al. 2015)
Presence of Organic Matter	Apparent External Dose, Uptake (co-solvent delivery)	(Yang et al. 2014; Collin et al. 2014)
Particle Charge and Coating	Uptake, Sensitivity to toxicity	(Ahn et al. 2014; Gonzalez-Moragas et al. 2017, Meyer et al. 2010a)
Particle Size	Uptake, Sensitivity to toxicity	(Ahn et al. 2014; Gonzalez-Moragas et al. 2017; Meyer et al. 2010a; Roh et al 2016)