Table 1.
The association between SIRT1 SNPs with mortality
| Minor allele copy number | n | HR (95% CI) | p value |
|---|---|---|---|
| SIRT1_366 (n = 7055) | |||
| Additive model | |||
| 0 | 5281 | Ref | |
| 1 | 1635 | 1.050 (0.963,1.146) | 0.269 |
| 2 | 139 | 1.209 (0.905,1.615) | 0.199 |
| Dominant model | |||
| 0 | 5281 | Ref | |
| 1 or 2 | 1774 | 1.059 (0.973,1.153) | 0.182 |
| Recessive model | |||
| 0 or 1 | 6916 | Ref | |
| 2 | 139 | 1.195 (0.895,1.595) | 0.227 |
| SIRT1_391 (n = 7077) | |||
| Additive model | |||
| 0 | 5006 | Ref | |
| 1 | 1887 | 1.023 (0.942,1.111) | 0.589 |
| 2 | 184 | 0.769 (0.603,0.981) | 0.035 |
| Dominant model | |||
| 0 | 5006 | Ref | |
| 1 or 2 | 2071 | 0.997 (0.92,1.081) | 0.947 |
| Recessive model | |||
| 0 or 1 | 6893 | Ref | |
| 2 | 184 | 0.764 (0.599,0.974) | 0.030 |
| SIRT1_773 (n = 7071) | |||
| Additive model | |||
| 0 | 3795 | Ref | |
| 1 | 2743 | 0.993 (0.919,1.072) | 0.854 |
| 2 | 533 | 0.960 (0.825,1.117) | 0.597 |
| Dominant model | |||
| 0 | 3795 | Ref | |
| 1 or 2 | 3276 | 0.988 (0.918,1.064) | 0.748 |
| Recessive model | |||
| 0 or 1 | 6538 | Ref | |
| 2 | 533 | 0.963 (0.831,1.116) | 0.616 |
| SIRT1_720 (n = 7046) | |||
| Additive model | |||
| 0 | 2292 | Ref | |
| 1 | 3383 | 1.045 (0.961,1.137) | 0.302 |
| 2 | 1371 | 1.013 (0.910,1.127) | 0.814 |
| Dominant model | |||
| 0 | 2292 | Ref | |
| 1 or 2 | 4754 | 1.036 (0.957,1.121) | 0.383 |
| Recessive model | |||
| 0 or 1 | 5675 | Ref | |
| 2 | 1371 | 0.986 (0.898,1.083) | 0.774 |
Note: All models were adjusted for age at baseline, sex, education, marriage, occupation, residence, exercise, smoking, and alcohol consumption