Table 3.

The interaction between PM_2.5 and SIRT1 SNPs (additive model) on mortality

Additive model	Model without interaction term		Model with interaction term
	HR (95% CI)	p value	β	SE	p value
Carrying SIRT1_366 minor allele status
0 copy	Ref	/	/	/	/
1 copy	1.059 (0.970,1.155)	0.200	0.248	0.171	0.147
2 copies	1.245 (0.931,1.663)	0.139	0.011	0.545	0.984
10-μg/m3 unit of PM2.5	1.083 (1.054,1.113)	7.04E-09	0.088	0.016	3.50E-08
Interaction term
zero SIRT1_366 minor allele×PM2.5	/	/	/	/	/
one SIRT1_366 minor allele×PM2.5	/	/	−0.037	0.032	0.249
two SIRT1_366 minor alleles×PM2.5	/	/	0.043	0.105	0.685
Carrying SIRT1_391 minor allele status
0 copy	Ref	/	/	/	/
1 copy	1.026 (0.944,1.114)	0.548	−0.255	0.167	0.127
2 copies	0.768 (0.602,0.980)	0.034	−1.452	0.577	0.012
10-μg/m3 unit of PM2.5	1.082 (1.053,1.112)	1.07E-08	0.06	0.016	2.64E-04
Interaction term
zero SIRT1_391 minor allele×PM2.5	/	/	/	/	/
one SIRT1_391 minor allele×PM2.5	/	/	0.054	0.031	0.081
two SIRT1_391 minor alleles×PM2.5	/	/	0.220	0.101	0.030
Carrying SIRT1_773 minor allele status
0 copy	Ref	/	/	/	/
1 copy	1.001 (0.926,1.081)	0.986	0.109	0.153	0.478
2 copies	0.951 (0.817,1.106)	0.513	−0.379	0.318	0.234
10-μg/m3 unit of PM2.5	1.082 (1.053,1.112)	1.19E-08	0.083	0.019	1.33E-05
Interaction term
zero SIRT1_773 minor allele×PM2.5	/	/	/	/	/
one SIRT1_773 minor allele×PM2.5	/	/	−0.021	0.029	0.464
two SIRT1_773 minor alleles×PM2.5	/	/	0.06	0.056	0.286
Carrying SIRT1_720 minor allele status
0 copy	Ref	/	/	/	/
1 copy	1.044 (0.960,1.135)	0.319	0.381	0.168	0.023
2 copies	1.001 (0.899,1.113)	0.992	0.201	0.223	0.366
10-μg/m3 unit of PM2.5	1.081 (1.052,1.111)	1.93E-08	0.117	0.024	1.45E-06
Interaction term
zero SIRT1_720 minor allele×PM2.5	/	/	/	/	/
one SIRT1_720 minor allele×PM2.5	/	/	−0.065	0.031	0.036
two SIRT1_720 minor alleles× PM2.5	/	/	−0.038	0.041	0.345

Note: All models were adjusted for age at baseline, sex, education, marriage, occupation, residence, exercise, smoking, and alcohol consumption