Table 2.
Bone marrow morphology for clinical cohort
| Patient characteristics | Sample features | Bone marrow differential (per 100 cells counted) | |||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Myeloid | Erythroid | Lymphoid | |||||||||||||||||||||
| Leukemia Subtype | Sample ID | Total Cellularity | Abnormal Infiltrate of immature cells | Megakaryocytes | Pro myelocyte | Myelocyte | Meta myelocyte | Band cells | Neutrophils | Eosinophils | Basophils | Monocyte | Pro Normoblast | Early Normoblast | Intermediate Normoblast | Late Normoblast | Blast cells | Pro lymphocyte | Lymphocyte | B lymphocyte | T lymphocyte | Natural Killer Cells | Plasma cells |
| B-ALL | B-01-Dx | Increased >95% | Present | Rare | - | - | - | - | - | - | - | - | - | 2 | - | 94 | - | 4 | - | - | - | - | |
| B-02-Dx | Increased | Present | Decreased | - | - | - | - | - | - | - | 1 | - | - | - | - | 97 | - | 2 | - | - | - | - | |
| B-03-Dx | Increased (100%) | Present | Present | - | - | 1 | - | - | - | - | 1 | - | - | - | - | 93 | - | 5 | - | - | - | - | |
| B-04-Dx | Increased (>95%) | Present | Present | - | - | 1 | - | - | - | - | - | - | - | 1 | - | 95 | - | 3 | - | - | - | - | |
| B-05-R1 | Increased | Present (80%) | Present | - | 1 | 4 | 2 | 2 | 2 | - | 4 | - | 4 | 12 | - | 68 | - | 1 | - | - | - | - | |
| B-06-R2 | Increased >95% | Present | Reduced | - | - | - | - | - | - | - | - | - | - | 1 | - | 96 | - | 3 | - | - | - | - | |
| B-06-R3 | Increased >95% | Present | Present | - | 2 | - | - | - | - | - | - | - | 1 | 3 | - | 90 | - | 4 | - | - | - | - | |
| B-07-R3 | ND | ND | ND | - | - | - | - | 2.31 | 0.77 | - | 0.77 | - | - | - | - | - | - | 6.93 | - | - | - | - | |
| B-08-R2 | Increased (100%) | Present | Rare | - | - | - | - | 1 | - | - | - | - | - | - | rare | 94 | 5 | - | - | - | - | - | |
| T-ALL | T-01-Dx | Increased >95% | Present | Present | - | - | - | 1 | 1 | 1 | - | - | - | 1 | 2 | - | 81 | - | 13 | - | - | - | - |
| T-01-R1 | Increasesd (95%) | Absent | Reduced | 2 | 4 | 5 | 6 | 27 | - | - | 1 | 1 | 2 | 4 | 40 | 2 | - | 6 | - | - | - | - | |
| T-02-Dx | Present | Reduced | - | - | - | 2 | 3 | - | - | - | - | - | 1 | 2 | 90 | - | 2 | - | - | - | - | ||
| T-LBL* | T-03-Dx | Low, normal (50 - 60%) | Present | Normal | 3 | 6 | 8 | 10 | 8 | 6 | - | 1 | 1 | 5 | 21 | 4 | 8 | - | 16 | - | - | - | 3 |
| Non-leukemic | NL-01 | Low, normal (50-60%) | None | Adequate | - | 10 | 18 | 9 | 18 | 2 | - | 2 | - | - | 16 | - | 0 | - | 25 | - | - | - | - |
| NL-02 | Reduced | None | Reduced, normal | 1 | 8 | 3 | 2 | 7 | 2 | 1 | 2 | 1 | 6 | 18 | 9 | 3 | - | 36 | - | - | - | 1 | |
Dx diagnosis, R Relapse, * = T-cell lymphoblastic lymphoma (T-LBL)