Table 2.

Clinical Variables and Risk Algorithm Calculation

Algorithm Clinical Variables	French Score	COMPERA	REVEAL 2.0
BNP/NT-proBNP, pg/ml	×	+1 if <300	−2 if <300
		+2 if ≤1,400	+2 if ≥1,100
		+3 if >1,400
NYHA class	+1 if ≤II	+1 if <III	−1 if I
		+2 if =III	+1 if III
		+3 if >III	+2 if IV
6-minute-walk distance, m	+1 if >440	+1 if >440	−2 if ≥440
		+2 if ≥165	−1 if >320
		+3 <165	+1 if <165
Right atrial pressure, mm Hg	+1 if <8	+1 if <8	+1 if >20
		+2 if ≤14
		+3 if >14
Sex	×	×	+2 if male and >60 yr
Age, yr	×	×	+2 if male and >60
Etiology	×	×	+1 if connective, +3 if portal, +2 if familial
Systolic blood pressure, mm Hg	×	×	+1 if <110
Heart rate, bpm	×	×	+1 if >96
Pulmonary vascular resistance, Wood units	×	×	−1 if <5
Renal function, ml/min/1.73 m2	×	×	+1 if <60
Recent hospitalizations	×	×	+1 if within 6 mo
Diffusing lung capacity, %DlCO	×	×	+1 if <40%
Pericardial effusion	×	×	+1 if present
Mixed venous oxygen saturation, %	×	+1 if >65	×
		+2 if ≥60
		+3 if <60
Cardiac index, L/min/m2	+1 if ≥ 2.5	+1 if ≥2.5	×
		+2 if ≥2
		+3 if <2
Final score	Sum total	Average of total available measurements	Sum total + 6

Definition of abbreviations: BNP = B-type natriuretic peptide; bpm = beats per minute; COMPERA = Comparative, Prospective Registry of Newly Initiated Therapies for Pulmonary Hypertension; NT-proBNP = N-terminal-proB-type natriuretic peptide; NYHA = New York Heart Association; REVEAL = Registry to Evaluate Early and Long-Term Pulmonary Arterial Hypertension Disease Management.

Clinical variables not included in the algorithm are marked with ×; clinical variables that were not available in any trial are underlined.