Table 4.
Incidence Rate and Treatment Effect per Risk Group as Defined by Risk Algorithm and Its Survival Tree Cut Points
| Algorithm | Risk Group | Pooled Placebo Incidence Rate of Clinical Worsening (Events per 100 Patient-Years) | Pooled Treatment Incidence Rate of Clinical Worsening (Events per 100 Patient-Years) | Hazard Ratio for Reduction of Clinical Worsening Rate (95% Confidence Interval) |
|---|---|---|---|---|
| French score | Low (2, 3) | 17.10 | 10.47 | 0.61 (0.46–0.81) |
| Intermediate (1) | 29.75 | 18.19 | 0.60 (0.46–0.79) | |
| High (0) | 51.44 | 25.08 | 0.50 (0.38–0.67) | |
| COMPERA | Low (≤1.7) | 13.90 | 8.27 | 0.59 (0.42–0.85) |
| Intermediate (>1.7–2.1) | 27.37 | 16.36 | 0.59 (0.46–0.76) | |
| High (>2.1) | 52.52 | 24.81 | 0.48 (0.37–0.62) | |
| REVEAL 2.0 | Very Low (≤5) | 11.00 | 6.61 | 0.60 (0.36–0.99) |
| Low (6–8) | 21.19 | 11.97 | 0.56 (0.42–0.74) | |
| Intermediate (9, 10) | 36.90 | 23.07 | 0.63 (0.48–0.83) | |
| High (>10) | 72.32 | 34.52 | 0.48 (0.34–0.67) | |
| NYHA | Low (≤ II) | 16.69 | 9.79 | 0.58 (0.43–0.78) |
| Intermediate (>II) | 35.02 | 20.95 | 0.60 (0.50–0.73) |
Definition of abbreviations: COMPERA = Comparative, Prospective Registry of Newly Initiated Therapies for Pulmonary Hypertension; NYHA = New York Heart Association; REVEAL = Registry to Evaluate Early and Long-Term Pulmonary Arterial Hypertension Disease Management.