Figure 1.

Proportion of liability explained in the general population. Estimated proportion of variation explained is taken from the liability R² from the regression analyses with the lower bound given when assuming a disease prevalence of 1.25 cases per 100,000 and the upper bound given when assuming a disease prevalence of 63 cases per 100,000. The gray bars show the estimated proportion of liability explained when assuming the disease prevalence in people >65 years of age of 495 cases per 100,000. The x-axis label “All 14 variants” refers to the model including all 14 sentinel idiopathic pulmonary fibrosis (IPF) susceptibility variants; “13 non-MUC5B” refers to the model including all sentinel IPF susceptibility variants minus the MUC5B polymorphism rs35705950. Variants are ordered by the proportion of explained variation.