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. Author manuscript; available in PMC: 2021 Aug 1.
Published in final edited form as: Eur J Heart Fail. 2020 Apr 1;22(8):1451–1461. doi: 10.1002/ejhf.1802

Figure 2. 7-α-thiomethyl-spironolactone concentrations in the ATHENA-HF trial.

Figure 2.

A) Previous low-dose stratum randomized to low-dose spironolactone (Low-dose group); B) Naïve stratum randomized to high-dose spironolactone group (High-dose-naïve group); C) Previous low-dose stratum randomized to high-dose spironolactone group (High-dose-previous group); D) Between group comparison at baseline, 48 and 96 hours. Data presented as median and interquartile range. All between group comparisons performed using Kruskal-Wallis test. *p < 0.05; # p < 0.005; †p < 0.0001