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. 2021 Mar 2;22(5):2500. doi: 10.3390/ijms22052500

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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(A) Cartoon representation of human δ ENaC’s extracellular domain (highlighted in tan) that is aligned to human α ENaC, coloured in slate grey. Extracellular domains of wt β (grey) and γ subunit (white) are shown as surface representation. The predicted localization of the inserted asparagines 292 (green) and 487 (purple) are highlighted together with the corresponding asparagines in α ENaC (N312 and 511, slate grey). (B) Solvent accessible surface representation of δ ENaC indicates that the inserted asparagine residues are localised at exposed positions.