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. 2021 Mar 2;22(5):2500. doi: 10.3390/ijms22052500

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Degradation of hyaluronic acid of the ECM reduces the shear force response of channels containing the N292/N487 construct. Wild type δβγENaC and δ^N292/N487βγ expressing oocytes were treated with hyaluronidase (hyal., grey bars). Hyaluronidase treatment had no effect on the shear force response of wild type δβγENaC, but reduced the shear force effect of δ^N292/N487βγ (ns, p > 0.05; *, p < 0.05; **, p < 0.01; one-way ANOVA with multiple comparisons). Representative current traces of these experiments are depicted in Figure S2.