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. 2021 Jan 28;8:630888. doi: 10.3389/fchem.2020.630888

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Copyright © 2021 Bijlmakers.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Trypanosomatid selective proteosome inhibitors. (A) structures of the inhibitors. (B) Cryo-EM structure of L. tarantulae proteosome complexed with GNF6702 (PDB 6QM7). The β5 subunits are in cyan, and the β4 subunits in blue. The inhibitor GNF6702 is in orange. (C) Detailed view of the inhibitor binding site located between the β4 and β5 subunits. The structure of the L. tarantulae proteosome with GNF6702 was overlayed with that of the L. tarantulae proteosome complexed with LXE408 (PDB6TCZ), showing the similar position of the two inhibitors. The residues of β4 that differ in human β4 are labeled.