Table 4.
Clinical and functional characteristics during hospitalization and at follow up in patients with DLCO ≥ 80% predicted and DLCO < 80% predicted.
| DLCO ≥ 80% Predicted (n = 13) | DLCO < 80% Predicted (n = 7) | |||||
|---|---|---|---|---|---|---|
|
|
During Hospitalisation | Follow up * | During Hospitalisation | Follow up * | p-Value | p-Value * |
| Chest CT patterns | ||||||
| TSS, points | 10.2 (6.0) | 6.4 (4.0) | 7.4 (3.5) | 6.0 (3.3) | 0.044 | 0.797 |
| Peripheral GGO, n (%) | 9 (69) | 5 (38) | 5 (71) | 4 (57) | 0.664 | 0.370 |
| Multifocal GGO, n (%) | 5 (38) | 10 (77) | 1 (14) | 6 (86) | 0.277 | 0.561 |
| Crazy paving, n (%) | 4 (31) | 1 (8) | 2 (29) | 0 (0) | 0.664 | 0.650 |
| Consolidation, n (%) | 9 (69) | 2 (15) | 4 (57) | 0 (0) | 0.474 | 0.411 |
| Fibrosis, n (%) | 8 (61) | 10 (77) | 4 (57) | 4 (57) | 0.608 | 0.336 |
| Post vs. ant. Prev., n (%) | 10 (77) | 10 (77) | 6 (86) | 6 (86) | 0.561 | 0.561 |
| Gas exchange parameters | ||||||
| FiO2, % | 24 (21–32) | 21 (0) | 21 (21–35) | 21 (0) | 0.316 | n/a |
| pH | 7.47 (7.44–7.48) | 7.45 (7.42–7.47) | 7.43 (7.42–7.44) | 7.44 (7.41–7.45) | 0.853 | 0.211 |
| PaCO2, mmHg | 39.8 (4.6) | 37.8 (4.1) | 42.1 (8.0) | 39.4 (5.5) | 0.404 | 0.457 |
| PaO2, mmHg | 76.5 (8.3) | 89.8 (13.1) | 83.1 (12.4) | 99.1 (15.9) | 0.169 | 0.173 |
| HCO3-, mmol/L | 28.3 (2.6) | 26.5 (2.2) | 27.2 (4.0) | 26.4 (3.6) | 0.452 | 0.933 |
| PaO2/FiO2, mmHg | 300 (74) | 427 (62) | 343 (109) | 472 (76) | 0.325 | 0.173 |
| A-a O2 gradient, mmHg | 38 (25–108) | 12 (6–20) | 18 (16–99) | 0.0 (0–0) | 0.126 | 0.056 |
| Lung function | ||||||
| FVC, %predicted | 63.1 (12.1) | 82.8 (15.7) | 81.6 (15.8) | 95.5 (13.8) | 0.023 | 0.082 |
| FEV1, %predicted | 67.6 (15.1) | 86.5 (15.8) | 88.6 (18.1) | 100.4 (9.2) | 0.012 | 0.047 |
| VC, %predicted | 62.6 (11.8) | 82.8 (17.3) | 88.6 (10.6) | 96.1 (9.8) | <0.001 | 0.077 |
| FEV1/VC, %predicted | 105.8 (18.5) | 105.1 (10.1) | 106.4 (13.6) | 104.7 (9.1) | 0.935 | 0.935 |
| TLC, %predicted | - | 80.0 (15.5) | - | 91.9 (13.7) | - | 0.119 |
| TLC >80%predicted, n (%) | 6 (54.5) | 1 (14.3) | 0.112 | |||
| IC, %predicted | - | 78.0 (23.1) | - | 96.0 (21.2) | - | 0.116 |
| RV, %predicted | - | 74.8 (24.5) | - | 94.6 (32.6) | - | 0.162 |
| DLco, %predicted | 48.3 (14.2) | 57.5 (14.1) | 70.2 (8.4) | 85.1 (6.6) | 0.002 | <0.001 |
| KCO, %predicted | 83.5 (20.5) | 86.4 (14.7) | 98.6 (12.5) | 101.8 (9.1) | 0.096 | 0.022 |
| VA, %predicted | 60.6 (13.4) | 69.4 (16.1) | 72.7 (12.3) | 86.4 (8.9) | 0.064 | 0.020 |
| VA/TLC | 0.87 (0.13) | 0.92 (0.1) | 0.394 | |||
| VA/VC | 0.67 (0.12) | 0.75 (0.06) | 0.75 (0.09) | 0.70 (0.08) | 0.159 | 0.102 |
Data are expressed as means (SD), median (IQR) and frequencies, as appropriate. Significant differences are in bold. TSS = total severity score; GGO = ground glass; A-a O2 gradient = alveolar arterial oxygen gradient; PaO2/FiO2 = arterial partial oxygen pressure to fraction of inspired oxygen ratio; PaCO2 = arterial partial carbon dioxide pressure; FEV1 = forced expiratory volume in one second; FVC = forced vital capacity; VC = vital capacity; LLN = lower limits of normal; RV = residual volume; IC = inspiratory capacity; TLC = total lung capacity; sRAWtot = specific total airway resistances; DLco = lung diffusion capacity for carbon monoxide; VA = alveolar volume; KCO = transfer factor for carbon monoxide.*comparison between the follow up observations.