Table 1.
Summary table of the proposed definitions of a pulmonary exacerbation in CF
| Criterion | Reference | |||||
|---|---|---|---|---|---|---|
| Fuchs 1994 [4] | Rosenfeld 2001[5] | Treggiari 2009[6] | Kraynack 2011[7] | Bilton 2011[8] | Regelmann 2013[9] | |
| Change in sputum | ✓ | ✓ | ✓ (minor) | ✓ | ✓ | ✓ |
| Haemoptysis | ✓ | ✓ (major) | ✓ | |||
| Increased cough | ✓ | ✓ | ✓ (minor) | ✓ | ✓ | ✓ |
| Increased dyspnoea or work of breathing | ✓ | ✓ (minor) | ✓ | ✓ | ||
| Increased malaise | ✓ | ✓ | ✓ | |||
| Temperature over 38°C |
✓ | ✓ | ||||
| Decreased appetite or weight loss | ✓ | ✓ | ✓ (minor) | ✓ | ✓ | ✓ |
| Sinus pain | ✓ | |||||
| Change in sinus discharge | ✓ | |||||
| Change in chest examination | ✓ | ✓ | ✓ (minor) | ✓ | ✓ | |
| Reduced pulmonary function by 10% or more | ✓ | ✓ (major) | ✓ | ✓ | ||
| Low oxygen saturation | ✓(major) | ✓ | ||||
| Radiographic changes | ✓ | ✓(major) | ✓ | ✓ | ||
| Decreased exercise tolerance | ✓ | ✓ (minor) | ✓ | |||
| School or work absenteeism | ✓ | ✓ | ||||
| Diagnosis of pulmonary exacerbation | New antibiotics AND 4/12 signs/symptoms | Score >2.6 based on a scoring system and the selected criterion | At least 1 major criteria OR 2 minor criteria with ≥5 day duration / significant symptom severity | Treatment with oral or intravenous antibiotics | Antibiotics AND 2 of the selected criterion | All the selected criterion |