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. Author manuscript; available in PMC: 2021 Mar 15.
Published in final edited form as: Nature. 2020 Jul 22;584(7819):148–153. doi: 10.1038/s41586-020-2546-8

Figure 1. Summary of predicted colchicine biosynthesis.

Figure 1.

The proposed pathway for colchicine biosynthesis is based on extensive radioisotope labeling studies and structural characterization of alkaloids isolated from colchicine-producing plants. The black circle in the structures of O-methylandrocymbine and colchicine indicates the rearrangement of carbon 12 (C12) during the ring expansion reaction. See Supplementary Information Scheme 1 for a full description of the proposed biosynthetic pathway.