. Author manuscript; available in PMC: 2021 Apr 1.

Published in final edited form as: Clin Rev Allergy Immunol. 2021 Apr;60(2):147–163. doi: 10.1007/s12016-020-08796-4

Table 1.

Biological features of pro-resolving receptors and associated SPMs

Receptor	Site of expression	SPM	Bioaction
ALX/FPR2	Neutrophils, eosinophils, airway epithelium, monocytes, macrophages, T cells, synovial fibroblasts, intestinal epithelial cells, human natural killer cells, and innate lymphoid cells	RvD1	Stimulate phagocytosis of apoptotic cells by macrophages
		RvD3
		LXA₄
		ATL
DRV1/GPR32	Neutrophils, lymphocytes, macrophages, monocytes, and vascular tissues	RvD1	Enhance macrophage-assisted phagocytosis of apoptotic cells
		AT-RvD1	Increase M2 macrophage polarization
		RvD3
		RvD5
		LXA₄
		ATL
DRV2/GPR18	Neutrophils, monocytes, and macrophages	RvD2	Promote non-phlogistic efferocytosis
			Inhibit chemotaxis of neutrophils
			Decrease pro-inflammatory cytokines
ERV1/ChemR32	Brain, kidney, cardiovascular, gastrointestinal, and myeloid tissues. Natural killer cells, innate lymphoid cells, dendritic cells, epithelial cells, naïve and M1 macrophages	RvE1	Promote phagocytosis of apoptotic PMNs by macrophages
ERV1/ChemR32		RvE2	Increase C-C chemokine receptor type 5 (CCR5) expression and reduce nuclear factor-kappa B (NF-kB) signaling
GPR37	Macrophages	NPD1	Promote phagocytosis of neutrophils by macrophages and resolve inflammatory pain
LRG6	Phagocytes	MaR1	Enhance phagocytosis, efferocytosis, and phosphorylation of several proteins including extracellular receptor kinase (ERK) and cAMP response element-binding protein (CREB)

ALX/FPR2 formyl peptide receptor 2, DRV1/GPR32 G protein-coupled receptor 32/resolvin D1 receptor, DRV2/GPR18 G protein-coupled receptor 18/resolvin D2 receptor, ERV1/ChemR32 chemokine receptor-like 1/E-series resolvin receptor, GPR37 G protein-coupled receptor 37, LGR6 leucine-rich repeat containing G protein-coupled receptor 6, LXA₄ lipoxin A₄, ATL aspirin-triggered 15-epi-lipoxin A₄, RvD1–5 resolvin D series, AT-RvD1 aspirin-triggered epimer resolvin D1, RvE1–2 resolvin E series, NPD1 neuroprotectin D1, MaR1 maresin 1, PMN polymorphonuclear neutrophils or polymorphonuclear leukocytes, CCR5 C-C chemokine receptor type 5, NF-kB nuclear factor kappa-light-chain-enhancer of activated B cells, ERK extracellular receptor kinase, cAMP cyclic adenosine monophosphate, CREB cAMP response element binding protein