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. Author manuscript; available in PMC: 2021 Dec 1.
Published in final edited form as: Mol Aspects Med. 2020 Jul 10;76:100869. doi: 10.1016/j.mam.2020.100869

Figure 1.

Figure 1

Diagram of AIM2 inflammasome activation. Double-stranded DNA released from bacteria, viruses, or damaged mitochondria binds to AIM2, inducing assembly of AIM2 inflammasome that consists of AIM2, ASC, and procaspase-1. Activated caspase-1 then cleaves pro-interleukin-1β and gasdermins to mediate inflammation and pyroptosis, respectively. Release of bacterial DNA into the cytoplasm relies on bacteriolysis mediated by interferon-inducible GTPases, whose expression is activated by cGAS-STING axis, also activated by cytoplasmic dsDNA.