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. Author manuscript; available in PMC: 2021 Mar 15.
Published in final edited form as: FEBS J. 2020 Jul 6;288(3):721–739. doi: 10.1111/febs.15450

Fig. 1.

Fig. 1.

Known Shoc2-interacting proteins, mapped to the N- or C-terminal region of Shoc2. Direct interaction of proteins in I and II with individual domains of Shoc2 was measured by yeast two-hybrid assay, binding assays using recombinantly expressed and purified GST-fusion proteins, or another biochemical strategy. Shoc2 LRR domain contains binding regions for PP1c (LRR4), the E3 ligases HUWE1 (LRR12-14), FBXW7 (LRR18), PSMC5 (LRRC), and VCP/p97 (LRR12-14). Proteins listed in III as ‘coimmunoprecipitated with Shoc2’ have not been shown to bind Shoc2 directly.