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. 2021 Mar 11;16:2137–2146. doi: 10.2147/IJN.S291001

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© 2021 Cheng et al.

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Ab-Vit.D-MNPs have the same therapeutic effect as vitamin D3 in ameliorating peritoneal functional deterioration in a peritoneal dialysis (PD) mouse model. (A) The ultrafiltration rate in the chlorhexidine gluconate (CG)-exposed group was significantly lower than that in the saline group; vitamin D3 corrected the CG-induced ultrafiltration decrease. The same therapeutic effect was observed in the Ab-Vit.D-MNP group. (B) The glucose mass transport also indicated that Ab-Vit.D-MNPs ameliorated the CG-induced increase in peritoneal permeability in the same way as vitamin D. (Data are represented as the mean ± SD, n ≥ 3; *P < 0.05, **P < 0.01, ***P < 0.001).