Table 2.

Ten-Fold AUROC statistics for unpenalized logistic regression prediction model on held out test data across all slides for colon (n=172) and LN (n=84); three head columns indicate whether advanced staging was predicted using aggregates of colon sub-compartment assignments (Region Counts); invasion (Tumor Invasion Scores); or Both to lend complementary information; models with main effects and interactions were considered; confidence assessed via 1000-sample non-parametric bootstrap

AUC (10-Fold CV)	Region Counts Only		Tumor Invasion Scores Only		Both
Stage > 2; LN Positive	Main Effects	Second Order Terms	Main Effects	Second Order Terms	Main Effects	Second Order Terms
Colon GNN Pretrained	0.89±0.028	0.85±0.031	0.84±0.032	0.89±0.028	0.91±0.022	0.85±0.031
Colon GNN Not Pretrained	0.89±0.027	0.88±0.028	0.86±0.029	0.89±0.027	0.91±0.023	0.88±0.028
LN GNN Pretrained	0.76±0.077	0.88±0.046	0.88±0.046	0.76±0.077	0.88±0.046	0.88±0.046
LN GNN Not Pretrained	0.89±0.051	0.92±0.039	0.92±0.034	0.89±0.051	0.92±0.037	0.92±0.039