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Flavopiridol mitigated the CRC malignancy induced by ZIC5. A – MTT assay indicated that flavopiridol restricted CRC cell proliferation induced by ZIC5 overexpression. B – Western blot results also showed the inhibitory effect of ZIC5 on the CDC25C/CDK1/cyclin B1 signaling pathway. C – Scratch assay revealed that flavopiridol inhibited CRC cell migration D – Flavopiridol inhibited ZIC5-overexpressing CRC cell invasion (***p < 0.001)
