Table 1:

Altered expression of CRAC channel proteins and their reported effects in different types of cancers

Cancer type	Cancer model	Change in expression of CARC channel protein	Effect	Reference
Breast	Microarray profiles of 295 human breast tumors	High STIM1, low STIM2	Associated with poor prognosis	45
Breast	MDA-MB-231, MC-7, T47D, BT-483	Elevated Orai1	Remodeling of Ca2+ influx associated with invasive stimuli	45
Breast	MCF-7 cells and cancerous breast tissue samples	High Orai3 expression	Promotes cell proliferation, cell cycle progression and apoptosis resistance	49
Cervical cancer	primary cervical cancer tissues	Overexpression of STIM1	Reduces five-year survival rate; Promotes tumor cell growth, cell cycle progression, migration, invasion and angiogenesis	50
Ovarian cancer	A2780cis (cisplatin resistant) cells	High Orai1 and STIM1 expression	Contributes to therapy resistance	52
Renal Cancer	ccRCC tissues	High expression of Orai1	Promotes cell proliferation and migration	53
Colorectal cancer	Patient tumor tissue specimen	STIM1 overexpression	Increases tumor size, invasion and migration	54
Colorectal cancer	SW620 and LOVO cells	STIM1 overexpression	Promotes metastasis and EMT	55
Colorectal cancer	Tissue microarray of 90 CRC patients	STIM1 overexpression	Indicative of poor prognosis	55
Gastric cancer	Tumor tissues from 327 GC patients	High Orai and STIM1 expression	Correlates with frequent recurrence and high mortality rate	57
Liver cancer	Hepatoma tissues and HCC cell lines	Higher expression of STIM1	Correlates with high metastatic potential in patients and higher migration ability in cell lines	58
Liver cancer	Hepatocarcinoma tissues	Elevated Orai1 expression	Serves as predictor of 5-FU sensitivity	59
Pancreatic cancer	Panc-1 cells	High expression of Orai1 and STIM1	Contributes to apoptosis resistance	60
Esophageal cancer	Tumor tissues from ESCC patients	Elevated expression of Orai1	Linked to poor overall and recurrence-free survival	61
Lung cancer	NSCLC tumor tissues	Higher STIM1 expression	Promotes tumorigenesis	62
Lung cancer	Tumor samples from 60 lung adenocarcinoma patients	Orai3 overexpression	Correlates with high tumor grade	63
Glioblastoma	U251 cells	Higher expression of STIM1	Promotes cell proliferation and invasion	65
Glioblastoma	Primary human cell lines established from glioblastoma surgical samples	Increased Orai1 levels	Promotes cell invasion	66
Glioblastoma	Tumor tissues from 61 glioma patients	Elevated Orai expression	Correlates with high tumor grade	67
Glioblastoma	Human glioma cell lines U251, SNB19, U87, and LN229	Elevated Orai expression	Promotes cell migration and invasion	67
Leukemia	HL60 cells	High expression of Orai2	Promotes cell migration	68
Multiple myeloma	Tumor tissues from 60 Multiple Myeloma patients	Increased expression of STIM1 and Orai1	Associated with poor prognosis	69
Multiple myeloma	KM3 and U266 cells	Increased expression of STIM1 and Orai1	Promotes cell growth and apoptosis resistance	69