Table 1.

Summary of major types of SCS approaches used in current research applications.

Research Applications	Representative Approaches	References
Genomic DNA profiling (SNV, CNV, CNA, etc.)	Typical SCS; single-cell exome sequencing	[39,40,41]
Transcriptome	Various scRNA-seq; Smart-Seq2	[25,57]
Newly synthesized and pre-existing RNAs	NASC-Seq	[58]
Non-coding RNA profiling	SMALL-seq; Holo-Seq	[59,60]
DNA methylome profiling	scBS-seq; scPBAT-seq	[61,62]
Histone modification	scChIP-seq	[53]
Chromatin structure (accessibility and interaction)	scATAC-seq; scHi-C; scDNase-seq	[48,59,60]
Genome and transcriptome	DR-Seq; G&T-Seq	[63,64]
Methylome and transcriptome	scM&T-Seq; scMT-Seq;	[65,66]
Genome, transcriptome and methylome	scTrio-Seq	[67]
Transcriptome and limited number of proteins	CITE-Seq; REAP-Seq; Ab-Seq	[68,69,70]
Transcriptome and chromatin accessibility	Sci-CAR	[71]