Table 1.
Cannabinoids and LPI.
| Substances | Targets | Behavior | Solvent | Concentration | Company | Article Number |
|---|---|---|---|---|---|---|
| ACEA | CB1 | agonist [61] | ethanol | 10 µM [11,15,16] | Tocris, Bristol, UK | 1319 |
| SMILES: CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(=O)NCCCl | ||||||
| AM281 | CB1 | antagonist [62] | DMSO | 1 µM [15,16] | Tocris, Bristol, UK | 1115 |
| SMILES: CC1=C(N(N=C1C(=O)NN2CCOCC2)C3=C(C=C(C=C3)Cl)Cl)C4=CC=C(C=C4)I | ||||||
| AM630 | CB2 | antagonist [63] | DMSO | 1 µM [15,16] | Tocris, Bristol, UK | 1120 |
| SMILES: CC1=C(C2=C(N1CCN3CCOCC3)C=C(C=C2)I)C(=O)C4=CC=C(C=C4)OC | ||||||
| Cannabidiol (CBD) | CB1 CB2 |
weak agonist [19] | DMSO | 5 µM [64] | Tocris, Bristol, UK | 1570 |
| GPR18 GPR55 |
antagonist [19] | |||||
| SMILES: CCCCCC1=CC(=C(C(=C1)O)C2C=C(CCC2C(=C)C)C)O | ||||||
| CID16020046 | GPR55 | antagonist [65] | DMSO | 10 µM (Figure S2) |
Tocris, Bristol, UK | 4959 |
| SMILES: CC1=CC=C(C=C1)C2=NNC3=C2C(N(C3=O)C4=CC=C(C=C4)C(=O)O)C5=CC(=CC=C5)O | ||||||
| Dronabinol (THC) | CB1 CB2 GPR18 GPR55 |
agonist [19] | DMSO | 5 µM [64] | THC pharm GmbH, Frankfurt am Main, Germany | THC-1016 |
| SMILES: CCCCCC1=CC(=C2C3C=C(CCC3C(OC2=C1)(C)C)C)O | ||||||
| JWH133 | CB2 | agonist [61] | DMSO | 10 µM [11,15,16] | Tocris, Bristol, UK | 1343 |
| SMILES: CCCC(C)(C)C1=CC2=C(C=C1)C3CC(=CCC3C(O2)(C)C)C | ||||||
| Lysophosphatidylinositol (LPI) | GPR55 | agonist [22] | DMSO | 1 µM [66] | Sigma-Aldrich® Chemie GmbH, Steinheim, Germany | L7635 |
| SMILES: CC(=O)OCC(COP(=O)(O)OC1C(C(C(C(C1O)O)O)O)O)O | ||||||
| O-1918 | GPR18 | antagonist [67] | DMSO | 30 µM [68] | Tocris, Bristol, UK | 2288 |
| SMILES: CC1=CC(C(CC1)C(=C)C)C2=C(C=C(C=C2OC)C)OC | ||||||