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. Author manuscript; available in PMC: 2021 Mar 15.
Published in final edited form as: Exp Neurol. 2020 Jan 18;327:113207. doi: 10.1016/j.expneurol.2020.113207

Figure 9. Simplified pathway for NAD metabolism.

Figure 9.

NAD+ is synthesized from two metabolic pathways: a de novo synthesis pathway from Na (and amino acids) or a recycling pathway. Sarm1 is a NAD+ consuming enzyme. Na: nicotinic acid; NaAD: nicotinic acid adenine dinucleotide; NAD+: nicotinamide adenine dinucleotide; NADSYN: Glutamine-dependent NAD(+) synthetase; NAM: nicotinamide; NaMN: nicotinic acid mononucleotide; NaMPT: Nicotinamide phosphoribosyltransferase; NaPRT: nicotinic acid phosphoribosyltransferase; NMN: nicotinamide mononucleotide; NMNAT: nicotinamide-nucleotide adenylyltransferase; Sarm1: Sterile Alpha and TIR Motif Containing 1; TBI: traumatic brain injury.