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. Author manuscript; available in PMC: 2021 Mar 15.
Published in final edited form as: Genes Brain Behav. 2012 Aug 4;11(8):993–1000. doi: 10.1111/j.1601-183X.2012.00827.x

Figure 3: HINT1 mediates nicotine-induced hypomotility at low nicotine doses.

Figure 3:

(a) Male HINT1 −/− mice are less sensitive to the locomotor depressant effects of nicotine compared with male HINT1 +/+ mice at the dose of 0.1 mg/kg. HINT1 −/− mice do not differ from +/+ counterparts at doses higher than 0.1 mg/kg. (b) Female HINT1 −/− mice are significantly less sensitive to the locomotor depressant effects of nicotine at 0.1 and 0.25 m/kg, but not at higher nicotine doses. Each point represents the mean ± SEM for 8–10 mice per group. * denotes P < 0.05 vs. corresponding +/+ group. ‘+ ’ denotes P < 0.05 vs. corresponding saline group for both genotypes. The x-axis represents nicotine doses administered and the y-axis represents the percentage of saline baseline.