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. 2021 Mar 11;13:2295–2306. doi: 10.2147/CMAR.S281377

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© 2021 Yu et al.

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Circ_0005927 sponged miR-942-5p to regulate BATF2. (A) The binding sites between miR-942-5p and BATF2 were predicted by TargetScan online database. (B and C) Dual-luciferase reporter assay was performed to verify that miR-942-5p bound to BATF2. (D) Western blot was carried out to detect the protein expression of BATF2 in NCM460, LoVo and SW620 cells. (E) QRT-PCR was employed to determine BATF2 mRNA expression in CRC tissues and normal intestinal tissues. (F and G) The linear relationship between BATF2 expression and circ_0005927 expression or miR-942-5p expression was explained by Spearman correlation analysis. (H) The interfering efficiency of anti-miR-942-5p was determined by qRT-PCR. (I) The effect of miR-942-5p inhibitor on the protein expression of BATF2 was disclosed by Western blot. (J) The impacts between circ_0005927 overexpression and miR-942-5p mimic on BATF2 protein expression were unveiled by Western blot. **P<0.01.