Figure 1.

Diagnostic workup of a patient with suspected MDS predisposition syndrome. The diagnostic workup of a patient with MDS predisposition syndrome includes personal and family history, physical examination, and laboratory testing. Identification of a MDS predisposition syndrome has several implications for clinical management, concerning surveillance, treatment choice and pre-transplant workup in case of progression requiring therapy, and subspecialty referrals. AML, Acute myeloid leukemia; CBC, Complete blood count; FISH, Fluorescent in situ hybridization; ICH, Immunohistochemistry; HLA, Human leukocyte antigen; HSCT, Hematopoietic stem cell transplantation; MDS, Myelodysplastic syndromes.