Figure 4.

Cardiac reactivity: heart rate modulation and functional neuroanatomy. Statistical parametric maps (SPMs) for the T-contrast (facial emotion > dynamic mosaic) in the svPPA and nfvPPA patient groups, with cardiac reactivity as predictor variable. Associations are shown separately for negative correlation with cardiac reactivity (i.e. BOLD signal predicting parasympathetic cardiac deceleration; top row) and positive correlation with cardiac reactivity (i.e. BOLD signal predicting sympathetic cardiac acceleration; bottom row). The plot (top right) shows mean cardiac reactivity (per cent change in heart rate from baseline) to facial expression stimuli by participant group (box and whisker plots display median, interquartile range, minimum and maximum values, with outliers appearing as red crosses). SPMs are thresholded at the cluster-defining threshold of P < 0.005 uncorrected and displayed on sections of the structural group mean T₁-weighted template brain image. The plane of each section (in mm in MNI space) is shown in the top right of each image; axial sections show the right hemisphere on the right. The colour bar codes T-values. bv = patient group with bvFTD; con = healthy control group; nfv = patient group with nfvPPA; sv = patient group with svPPA.