Table 3.

Functional neuroanatomical associations of emotion identification and physiological responses

Group	Region	Side	Cluster (voxels)	Peak (mm)			PFWE
				x	y	z
Emotion identification performance (after covarying for semantic ability)
bvFTD	Anterior insula	Left	167	−24	29	11	0.009
	Caudate	Left	–	−15	11	8	–
svPPA	Temporal pole	Right	4	36	2	−37	0.015*
nfvPPA	Frontal operculum	Right	100	48	11	11	0.023*
Cardiac parasympathetic activitya
svPPA	Fusiform gyrus	Left	166	−36	−28	−16	0.008
	Middle temporal gyrus	Left	142	−57	−49	−16	0.019
	Superior frontal gyrus	Left	131	−18	−1	68	0.028
	Fusiform gyrus	Right	49	18	−76	−16	0.033*
nfvPPA	Dorsolateral prefrontal	Right	3023	36	38	17	<0.001
	Medial prefrontal	Right	–	18	22	49	–
		Left	–	−6	42	33	–
	Anterior cingulate	Right	–	10	45	11	–
		Left	–	−10	48	16	–
	Caudate	Left	–	−9	2	14	–
	Insula	Right	–	43	2	−2	–
	Frontal operculum	Left	343	−42	20	8	<0.001
	Superior temporal sulcus	Right	122	48	−34	1	0.040
Cardiac sympathetic activityb
nfvPPA	Orbitofrontal cortex	Right	346	15	5	−19	<0.001
	Temporoparietal junction	Right	160	45	−34	29	0.010
	Pons	Right	119	1	−25	−32	0.045
	Lateral medulla	Right	–	14	−29	−44	–
		Left	–	−7	−27	−44	–
	Insula	Left	76	−36	−1	−13	<0.001*
Pupil activity
svPPA	Angular gyrus	Left	186	−42	−64	59	0.004
		Right	122	45	−40	41	0.039
	Fusiform gyrus	Left	129	−18	−52	−7	0.030
		Right	37	42	−67	−16	0.017*
	Temporal pole	Left	68	−27	14	−31	0.001*
nfvPPA	Anterior cingulate	Right	62	12	17	23	0.045*

The table presents functional MRI correlates for the specified response measures at second level within each syndromic group. Voxel coordinates of local maxima within significant clusters are in standard MNI stereotactic space. P-values represent cluster-level FWE-corrected values over the whole brain, except *peak-level FWE-corrected within pre-specified regions of interest.

^aNegative association with heart rate change.

^bPositive association with heart rate change.