Fig 7. Classification of the anthelmintic effect determined for pairwise drug combinations of selected HDAC inhibitors and albendazole (ABZ).

The proportional effect indices were determined for all binary drug combinations of HDAC inhibitors and ABZ tested. The values are displayed in a heat-map format to display the deviation away the different combinations’ merely additive predicted effects. Index values range from -1 to +1. The predicted additive effect index (0) is depicted in yellow. If the effect determined for the pair of compounds is higher than the predicted outcome, it is indicated in green; if the determined effect is lower, it is indicated in red. The proportional effect indices were calculated from three independent biological replicates, each in quadruplicate.