Table 1. In vitro anthelmintic activity of selected HDAC inhibitors and albendazole (ABZ) in Mesocestoides vogae.
Compound | Dose-response relationship parametersa | ||
---|---|---|---|
IC25 ± SD [µM] | IC50 ± SD [µM] | IC90 ± SD [µM] | |
Entinostat | 0.91 ± 0.07 | 1.22 ± 0.07 | 2.39 ± 0.32 |
TH65 | 9.18 ± 1.84 | 11.45 ± 1.20 | 17.03 ± 3.84 |
TH92 | 4.97 ± 0.46 | 6.27 ± 0.58 | 10.58 ± 2.52 |
ABZ | 15.82 ± 0.56 | 20.59 ± 0.38 | 36.01 ± 2.00 |
a The reported values were calculated from three independent biological replicates, each one in quadruplicate, and were expressed with their respective standard deviations (SD).