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. 2021 Mar 3;15(3):e0009226. doi: 10.1371/journal.pntd.0009226

Table 1. In vitro anthelmintic activity of selected HDAC inhibitors and albendazole (ABZ) in Mesocestoides vogae.

Compound Dose-response relationship parametersa
IC25 ± SD [µM] IC50 ± SD [µM] IC90 ± SD [µM]
Entinostat 0.91 ± 0.07 1.22 ± 0.07 2.39 ± 0.32
TH65 9.18 ± 1.84 11.45 ± 1.20 17.03 ± 3.84
TH92 4.97 ± 0.46 6.27 ± 0.58 10.58 ± 2.52
ABZ 15.82 ± 0.56 20.59 ± 0.38 36.01 ± 2.00

a The reported values were calculated from three independent biological replicates, each one in quadruplicate, and were expressed with their respective standard deviations (SD).