Figure 1.

The genomic landscape of PTM-disrupting mutations (PTM^mut) in the tumor matrisome and in the rest of the genome. Dimensions of the analysis (A) and comparison between the tumor matrisome and rest of the tumor genome for overall mutation frequency (B) and type of mutation (C). PTM^mut are a minority of all matrisome mutations (D) with significant enrichments or depletions of PTM types affected (E). The amount of PTM^mut across tumors and divided by matrisome family (F) is negatively correlated with preservation of the PTM^mut (indicating poor preservation of a given PTM^mut in multiple patients (or cancer types) and (G) varies considerably across the different types of PTM investigated. Abbreviations: n.s., not significant; ECM-AP, ECM-affiliated proteins; ECM-G, ECM glycoproteins; ECM-R, ECM regulators; SF, secreted factors. p-values are from Chi-square tests.