Figure 1.

Representative images of the three major histopathological growth patterns (HGPs) in colorectal liver metastases identified on H&E-stained tissue sections: (A) replacement HGP, characterized by tumor cells infiltrating the surrounding liver parenchyma (IM region). (B) pushing HGP, recognized by the liver tissue compressed and pushed away by the tumor (IM region between the two dotted lines) and (C) desmoplastic HGP, identified by a rim of fibrotic tissue that encapsulates the metastasis (IM region between the two dotted lines). Scale bar: 50 μm. PT: peritumor, IM: invasive margin, TU: tumor regions.