Table 1.
KRAS-G12D–specific T cell receptors
| Patient no. | TCR name | V alpha | V beta | CDR3α (length) | CDR3β (length) | TCR frequency (infusion), % | TCR frequency (post transfer), % | KRASG12D specificity |
| 4095 | 9a | TRAV4*01 | TRBV5-6*01 | CLVGDMDQAGTALIF (13) | CASSLGEGRVDGYTF (13) | 50 | 0 | 10GADGVGKSA |
| 4095 | 9b | TRAV4*01 | TRBV5-6*01 | CLVGDMDQAGTALIF (13) | CASSLGRASNQPQHF (13) | 0.04 | 0.005 | 10GADGVGKSA |
| 4095 | 9c | TRAV4*01 | TRBV5-6*01 | CLVGDRDQAGTALIF (13) | CASSFGQSSTYGYTF (13) | 7 | 4.5 | 10GADGVGKSA |
| 4095 | 10 | TRAV12-2*01 | TRBV10-2*01 | CAAAMDSSYKLIF (11) | CASSDPGTEAFF (10) | 20 | 10 | 10GADGVGKSAL |
| 3995 | 9d | TRAV4*01 | TRBV5-6*01 | CLVGDMDQAGTALIF (13) | CASSLGQTNYGYTF (12) | 0.002 | 0 | 10GADGVGKSA |