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. 2020 Oct 16;117(44):27445–27455. doi: 10.1073/pnas.2012088117

Fig. 5.

Fig. 5.

Azelaic acid inhibits growth of A. macleodii F12 and promotes growth of Roseobacters. Growth of (A) S. pseudonitzschiae F5, (B) Phaeobacter sp. F10, and (C) A. macleodii F12 on 10% marine broth supplemented with 100 µM azelaic acid (squares) compared to controls (circles). Error bars represent SD of three replicates. Significance was determined by Student’s t test: *P < 0.05 and **P < 0.001. (D) Bacterial response to azelaic acid is geographically widespread throughout the oceans. The relative abundance of reads of the azelaic acid transcriptional regulator, AzeR, in the Tara Oceans database is 0.03%. The total percentage abundance of AzeR homologs according to their taxonomic distribution is shown in the top right box. Rhizobiales makes up the majority of hits (39%) in the “other” group. The color-coded donut plots represent the percentage taxonomic abundance of AzeR homologs from all size fractions (0 to 3 μm) at the surface (inner circle) and deep chlorophyll maximum (outer circle) from the Tara Oceans Microbiome Reference Gene Catalog. Numbers refer to the Tara Oceans stations; single donut plots depict surface samples only.