Table 3.

Associations between the four polygenetic scores and 2-year changes in glycemic traits in white participants

Outcomes	WHRonly+		BMIonly+		BMI+WHR+		BMI+WHR−
	β(SE)	P	β(SE)	P	β(SE)	P	β(SE)	P
Δ BMI, kg/m2	−0.05(0.04)	0.13	−0.12(0.05)	0.01	−0.03(0.02)	0.19	−0.01(0.04)	0.69
Δ Waist, cm	0.01(0.05)	0.89	−0.05(0.07)	0.48	−0.01(0.03)	0.80	−0.16(0.05)	0.002
Δ Glucose, mg/dL	−0.05(0.12)	0.69	−0.03(0.16)	0.87	0.01(0.07)	0.87	−0.09(0.12)	0.46
Δ Insulin, μU/mL	−0.001(0.005)	0.87	−0.0003(0.007)	0.96	−0.0002(0.003)	0.95	−0.006(0.005)	0.27
Δ HOMA-B	−0.002(0.005)	0.75	−0.0003(0.007)	0.97	−0.001(0.003)	0.76	−0.001(0.005)	0.84
Δ HOMA-IR	−0.0005(0.006)	0.93	−0.0005(0.007)	0.95	−0.00005(0.003)	0.99	−0.007(0.006)	0.23

β represents changes in each outcome per increment of 1 PGS. P for trend between the four PGSs and changes in BMI, waist circumference and glycemic traits was calculated by applying general linear models, after adjustment for age, sex, diet group, baseline BMI, 2-year weight change (except BMI change), and baseline values for respective phenotypes (except BMI change). Data on insulin, HOMA-B, HOMA-IR were log-transformed before analysis. HOMA-B, homeostasis model assessment of β cell function; HOMA-IR, insulin resistance.