Table 7. Association of the top pathways with the disease under study.
“Dataset” indicates the dataset GEO ID.
| Dataset | Investigated disease | ID | Pathway | Literature support | PMID |
|---|---|---|---|---|---|
| GSE15573 | Rheumatoid Arthritis | hsa04932 | Non-alcoholic fatty liver disease (NAFLD) | None | None |
| GSE15574 | Rheumatoid Arthritis | hsa04120 | Ubiquitin mediated proteolysis | Aberration of this system leads to the dysregulation of cellular homeostasis and the development of multiple inflammatory and autoimmune diseases, including rheumatoid arthritis. | 16978533 |
| GSE15575 | Rheumatoid Arthritis | hsa05016 | Huntington disease | None | None |
| GSE15576 | Rheumatoid Arthritis | hsa04714 | Thermogenesis | None | None |
| GSE15577 | Rheumatoid Arthritis | hsa04723 | Retrograde endocannabinoid signaling | Endocannabinoids, a group of endogenous bioactive lipids, have immunomodulatory effects able to influence both inflammation and pain in rheumatic disease, including rheumatoid arthritis. | 29164003, 28857069 |
| GSE15578 | Rheumatoid Arthritis | hsa05010 | Alzheimer disease | None | None |
| GSE15579 | Rheumatoid Arthritis | hsa04140 | Autophagy | Deregulation of autophagic pathway has recently been implicated in the pathogenesis of several autoimmune diseases, including rheumatoid arthritis. | 30072986 |
| GSE15580 | Rheumatoid Arthritis | hsa04621 | NOD-like receptor signaling pathway | NOD-like receptors are being implicated in the pathology of RA and other rheumatic diseases. | 19835640 |
| GSE15581 | Rheumatoid Arthritis | hsa05012 | Parkinson disease | None | None |
| GSE15582 | Rheumatoid Arthritis | hsa05203 | Viral carcinogenesis | None | None |
| GSE4107 | Colorectal Cancer | hsa04915 | Estrogen signaling pathway | None | None |
| GSE4107 | Colorectal Cancer | hsa04662 | B cell receptor signaling pathway | None | None |
| GSE4107 | Colorectal Cancer | hsa04012 | ErbB signaling pathway | ERBB pathway may have a role in both normal colon epithelial cell differentiation and malignant transformation. | 27270421 |
| GSE4107 | Colorectal Cancer | hsa05140 | Leishmaniasis | None | None |
| GSE4107 | Colorectal Cancer | hsa05224 | Breast cancer | None | None |
| GSE4107 | Colorectal Cancer | hsa04510 | Focal adhesion | Cancer cells exhibit highly altered focal adhesion dynamics. | 28476046 |
| GSE4107 | Colorectal Cancer | hsa04210 | Apoptosis | Abnormalities in apoptotic function contribute to both the pathogenesis of colorectal cancer and its resistance to chemotherapeutic drugs and radiotherapy. | 15479695 |
| GSE4107 | Colorectal Cancer | hsa04010 | MAPK signaling pathway | MAPK signaling plays an important part in progression of colorectal cancer. | 15863380 |
| GSE4107 | Colorectal Cancer | hsa05166 | Human T-cell leukemia virus 1 infection | None | None |
| GSE4107 | Colorectal Cancer | hsa05200 | Pathways in cancer | "Meta"-pathway of cancer pathways. | None |
| GSE55945 | Prostate Cancer | hsa04110 | Cell cycle | Dysregulation of the cell cycle is implicated in the biology of many cancers, including PCa. | 7997877, 9096291, 18301781 |
| GSE55945 | Prostate Cancer | hsa04360 | Axon guidance | None | None |
| GSE55945 | Prostate Cancer | hsa04390 | Hippo signaling pathway | The hippo pathway effector YAP regulates motility, invasion, and castration-resistant growth of prostate cancer cells. | 25645929 |
| GSE55945 | Prostate Cancer | hsa05166 | Human T-cell leukemia virus 1 infection | None | None |
| GSE55945 | Prostate Cancer | hsa04014 | Ras signaling pathway | Ras signaling plays an important role in prostate cancer progression and is a possibly mediator of hormone resistance. | 14689577, 20718703 |
| GSE55945 | Prostate Cancer | hsa01040 | Biosynthesis of unsaturated fatty acids | Alterations in lipid metabolism, and specifically the uptake and synthesis of fatty acids (FAs), comprise a well-documented aspect of metabolic reprograming in cancer. | 31598388 |
| GSE55945 | Prostate Cancer | hsa05163 | Human cytomegalovirus infection | None | None |
| GSE55945 | Prostate Cancer | hsa04350 | TGF-beta signaling pathway | TGF-beta signaling has pivotal roles in tumorigenesis and tumor progression | 26774024, 29115550 |
| GSE55945 | Prostate Cancer | hsa04010 | MAPK signaling pathway | MAPK signaling pathways act through their effects on apoptosis, survival, metastatic potential, and androgen-independent growth in prostate cancer | 22046506 |
| GSE55945 | Prostate Cancer | hsa04933 | AGE-RAGE signaling pathway in diabetic complications | None | None |
Note:
“Investigated Disease” indicates the disease investigated by the study. “ID” and “Pathway” indicate the KEGG ID and pathway name of the top pathway, respectively. “Literature support” provides a brief summary of literature support for the pathway-disease association. “PMID” indicates the PubMed ID(s) of the supporting study/studies.