Table 2. Number of relation edges and participating entities in each relation of subset of Hetionet dataset.

The semantic of each relation is as follows: treats relation: compound–treats–disease; presents relation: disease–presents–symptom; associates relation: disease–associates–gene; causes relation: compound–causes–sideeffect.

Relation	# of relation edges	# of source entities	# of destination entities
treats relation	755	387 (Drugbank)	77 (Disease ontology)
presents relation	3,357	133 (Disease ontology)	415 (MeSH)
associates relation	12,623	134 (Disease ontology)	5,392 (Entrez Gene)
causes relation	138,944	1,071 (Drugbank)	5,701 (SIDER)